UMC Utrecht, Utrecht, The Netherlands
Associate professor Jacqueline Alblas is PI bone regeneration at the department of Orthopaedics, University Medical Center Utrecht. She has wide experience in bone regenerative medicine, where the main focus is to develop hybrid constructs in which scaffold material and cell stimuli are optimally combined with the regenerative potential of adult stem cells. Important expertise is present with respect tissue architecture, (neo)vascularization, gene delivery and immunological aspects of bone substitutes. The interaction of bone with the immune system is an important research theme, in particular with respect to the use of allogeneic cells. This is complemented by investigations of the influence of immune cells and (bacterially derived) inflammatory mediators on bone regeneration.
Printing of living cells, which was developed in her group since 2005, has received a lot of attention in the last years, and has expanded considerably. Using this technology, dedicated biomaterials suitable for bioprinting have been designed and optimized and are now being employed in intricate prevascularized bone replacement constructs. They are used to investigate the role of self-organisation of cells and matrix components in tissue repair and also act as model systems for bone-residing diseases, such as multiple myeloma. She is supervising several projects within the public-private domain, and has published over 50 articles in peer reviewed international journals (h-index = 24).